Heidi Schmidt
Radiologist-in-Chief, Program Medical Director, JDMI
Dr. Heidi Schmidt is the Radiologist-in-Chief of the Joint Department of Medical Imaging (JDMI) at the University Health Network, Sinai Health and Women’s College Hospital in Toronto, and Professor of Radiology at the University of Toronto.
She trained in Germany, where she finished her residency in diagnostic radiology in 1993. Following a research fellowship at the University of California, San Francisco (UCSF) in 1994, Dr. Schmidt was on faculty of the Department of Radiology at UCSF until 2002.
After her recruitment to Toronto in 2002, her research focused on lung cancer screening using low-dose computed tomography, both as a site in the International Early Lung Cancer Action Program (I-ELCAP), as well as a site in the Pan-Canadian Early Lung Cancer Detection Study. Since 2017, Dr. Schmidt is the Radiology Quality Lead of the High Risk Lung Cancer Screening Pilot at Cancer Care Ontario.
- Obesity accelerates acute promyelocytic leukemia in mice and reduces sex differences in latency and penetrance
CONCLUSIONS: Obesity and obesogenic diet promote the development of APL in vivo, reducing sexual dimorphisms in disease latency and penetrance.
- Restoring Timely Access to Medical Imaging in Canada: A Prescription for Renewed Radiology Investments
No abstract
- Lung Cancer Screening in Persons Who Never Smoked Has to be Evaluated-A Response to Letter to the Editor
No abstract
- Screening for Lung Cancer in Individuals Who Never Smoked: An International Association for the Study of Lung Cancer Early Detection and Screening Committee Report
Screening with low-dose computed tomography of high-risk individuals with a smoking history reduces lung cancer mortality. Current screening […]
- Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation: Mid-Career Award for Research Excellence 2020
The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance […]
- Human and rodent red blood cells do not demonstrate xanthine oxidase activity or XO-catalyzed nitrite reduction to NO
A number of molybdopterin enzymes, including xanthine oxidoreductase (XOR), aldehyde oxidase (AO), sulfite oxidase (SO), and mitochondrial amidoxime […]
- [Ni(NHC)2 ] as a Scaffold for Structurally Characterized trans [H-Ni-PR2 ] and trans [R2 P-Ni-PR2 ] Complexes
The addition of PPh(2) H, PPhMeH, PPhH(2) , P(para-Tol)H(2) , PMesH(2) and PH(3) to the two-coordinate Ni⁰ N-heterocyclic carbene species […]
- Selection of individuals for lung cancer screening based on risk prediction model performance and economic factors - The Ontario experience
CONCLUSIONS: The PLCOm2012 was efficiently implemented in the Pilot in a real-world setting and is being used to transition into a provincial […]
- CoenzymeQ in cellular redox regulation and clinical heart failure
Coenzyme Q (CoQ) is ubiquitously embedded in lipid bilayers of various cellular organelles. As a redox cycler, CoQ shuttles electrons between […]
- Risk Perception Among a Lung Cancer Screening Population
BACKGROUND: A successful lung cancer screening program requires a patient cohort at sufficient risk of developing cancer who are willing to […]
- Xanthine Oxidase Drives Hemolysis and Vascular Malfunction in Sickle Cell Disease
CONCLUSIONS: Ten weeks of febuxostat treatment significantly decreased hemolysis and improved pulmonary vasoreactivity in a mouse model of SCD. […]
- Chronic obstructive pulmonary disease prevalence and prediction in a high-risk lung cancer screening population
CONCLUSIONS: COPD had a high prevalence in a lung cancer screening population. While a risk model had poor discrimination, all deciles of risk had a […]
- Organized Lung Cancer Screening Pilot: Informing a Province-Wide Program in Ontario, Canada
CONCLUSIONS: The pilot is the largest in Canada and aligns with International Agency for Research on Cancer standards for population-based, organized […]
- Prediction of lung cancer risk at follow-up screening with low-dose CT: a training and validation study of a deep learning method
BACKGROUND: Current lung cancer screening guidelines use mean diameter, volume or density of the largest lung nodule in the prior computed tomography […]
- Hepatic Stellate Cell-Specific Platelet-Derived Growth Factor Receptor-α Loss Reduces Fibrosis and Promotes Repair after Hepatocellular Injury
Platelet-derived growth factor receptor (PDGFR)-α plays roles in cell survival, proliferation, and differentiation; however, its function in chronic […]
- The International Association for the Study of Lung Cancer Early Lung Imaging Confederation
CONCLUSION: This initiative can rapidly accelerate improvements to the multidisciplinary management of early, curable lung cancer and other major […]
- Trial marketing in the Pan-Canadian Early Detection of Lung Cancer Study
CONCLUSION: A survey of trial candidates provides useful information regarding personal motivation, media use, and lifestyle. Unpaid media events […]
- Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice
Pulmonary and systemic vasculopathies are significant risk factors for early morbidity and death in patients with sickle cell disease (SCD). An […]
- Loss of smooth muscle CYB5R3 amplifies angiotensin II-induced hypertension by increasing sGC heme oxidation
Nitric oxide regulates BP by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMCs). […]
- Outcomes of Long-term Interval Rescreening With Low-Dose Computed Tomography for Lung Cancer in Different Risk Cohorts
CONCLUSIONS: There was a significantly higher incidence of LC in the high-risk cohort than in the moderate-risk cohort. The cut-point between the […]
- Health-related quality of life and anxiety in the PAN-CAN lung cancer screening cohort
CONCLUSIONS: CT screening for lung cancer has no major overall impact on HRQoL among participants, although a minority of participants […]
- The impact of xanthine oxidase (XO) on hemolytic diseases
Hemolytic diseases are associated with elevated levels of circulating free heme that can mediate endothelial dysfunction directly via redox reactions […]
- Predicting Malignancy Risk of Screen-Detected Lung Nodules-Mean Diameter or Volume
CONCLUSION: Either CAD-based nodule diameter or volume can be used to assist in predicting a nodule's malignancy risk.
- Importance of Long-term Low-Dose CT Follow-up after Negative Findings at Previous Lung Cancer Screening
Purpose To assess the incidence of lung cancer in a cohort of patients with negative findings at previous lung cancer screening. Materials and […]
- Advanced Technologies for Imaging and Visualization of the Tracheobronchial Tree: From Computed Tomography and MRI to Virtual Endoscopy
Advanced imaging plays an increasingly important role in the evaluation of the trachea. The use of computed tomography (CT) has evolved to include […]
- Optimal imaging surveillance after stereotactic ablative radiation therapy for early-stage non-small cell lung cancer: Findings of an International Delphi Consensus Study
CONCLUSIONS: These guidelines provide international expert consensus on areas of uncertainty in the management of early-stage non-small cell lung […]
- Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study
BACKGROUND: Results from retrospective studies indicate that selecting individuals for low-dose CT lung cancer screening on the basis of a highly […]
- Hypermobility in Adolescent Athletes: Pain, Functional Ability, Quality of Life, and Musculoskeletal Injuries
Study Design Cross-sectional. Background Generalized joint hypermobility (GJH) may increase pain and likelihood of injuries and also decrease […]
- Canadian Association of Radiologists: Guide on Computed Tomography Screening for Lung Cancer
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- The Cost-Effectiveness of High-Risk Lung Cancer Screening and Drivers of Program Efficiency
CONCLUSIONS: Non-lung cancer outcomes drive screening efficiency in diverse, tobacco-exposed populations. Use of risk selection can reduce the budget […]