Claudia Ortega
Dr. Claudia Ortega is a staff radiologist at the Joint Department of Medical Imaging (UHN, Sinai Health and Women’s College Hospital), with cross appointment in Molecular Imaging and Abdominal Division.
She graduated from the Faculty of Medicine at the University of Santiago, Chile, and completed her residency training at the Catholic University of Chile. After being a staff radiologist and Associated professor in her forming centre (Catholic University), Dr. Ortega pursued an Abdominal Fellowship and two years of combined Research and Clinical fellowship at the Molecular Imaging division at University of Toronto.
She is affiliated with multiple international professional societies including the Radiological Society of North America, Society of Nuclear Medicine, and the Chilean Radiology Society.
Dr. Ortega’s main clinical and research interests are in hybrid imaging (PET/CT and PET/MR) for tumour detection as well as in characterization and assessment of response to therapy with functional imaging. Most of her recent publications are focused on prostate molecular imaging and neuroendocrine tumours.
Dr. Ortega enjoys spending time with her family, cooking and travelling – especially back to Chile to see her family, the Andes and the Pacific Ocean).
- Nasopharyngeal Carcinoma Radiomic Evaluation with Serial PET/CT: Exploring Features Predictive of Survival in Patients with Long-Term Follow-Up
CONCLUSIONS: This study with long-term follow up data on NPC suggests that mainly PET-derived radiomic features are predictive for OS but not PFS in […]
- Diagnostic performance of [18F]-FDG PET/MR in evaluating colorectal cancer: a systematic review and meta-analysis
CONCLUSION: This meta-analysis showed an overall high diagnostic performance for [^(18)F]-FDG PET/MR in detecting CRC lesions/metastases. Thus, this […]
- Impact of 18F-DCFPyL PET on Staging and Treatment of Unfavorable Intermediate or High-Risk Prostate Cancer
Background Data regarding 2-(3-{1-carboxy-5-[(6-[^(18)F]fluoro-pyridine 3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid (^(18)F-DCFPyL) PET in […]
- Combined 18 F-FDG PET/CT Radiomics and Sarcopenia Score in Predicting Relapse-Free Survival and Overall Survival in Patients With Esophagogastric Cancer
CONCLUSIONS: PET and CT radiomics derived from combined PET/CT integrated with clinicopathological parameters and sarcopenia measurement might […]
- The impact of PSMA PET on the treatment and outcomes of men with biochemical recurrence of prostate cancer: a systematic review and meta-analysis
CONCLUSION: In conclusion, PSMA PET is positive in more than 2/3 of men with BCR and impacts patient management in more than half of the men. BRFS […]
- Overcoming the Solubility Problem in E. coli: Available Approaches for Recombinant Protein Production
Despite the importance of recombinant protein production in the academy and industrial fields, many issues concerning the expression of soluble and […]
- The association between lesion tracer uptake on 68Ga-DOTATATE PET with morphological response to 177Lu-DOTATATE therapy in patients with progressive metastatic neuroendocrine tumors
CONCLUSION: In patients with SSTR-RADS 5 PM-NETs treated with 177Lu-DOTATATE, there was similar response to therapy for all lesions with […]
- Production, purification and characterization of a double-tagged TEV protease
Many recombinant proteins are products of great value in biomedical and industrial fields. The use of solubility and affinity tags are commonly used […]
- Somatic hypermutation profiles in stereotyped IGHV4-34 receptors from South American chronic lymphocytic leukemia patients
Chronic lymphocytic leukemia (CLL) is the most common mature B-cell neoplasm in the West. IGHV4-34 is one of the most frequently used genes in CLL […]
- Influence of sarcopenia, clinical data, and 2-[18F] FDG PET/CT in outcome prediction of patients with early-stage adenocarcinoma esophageal cancer
CONCLUSION: Combining the patients' imaging-derived sarcopenic status with standard clinical data, but not metabolic parameters, offered an overall […]
- 18F-DCFPyL (PSMA) PET in the Management of Men with Biochemical Failure after Primary Therapy: Initial Clinical Experience of an Academic Cancer Center
CONCLUSION: ^(18)F-DCFPyL PET was positive in >90% of patients with biochemical failure. For those with limited recurrence, PSMA PET-directed […]
- Deep learning for whole-body medical image generation
CONCLUSION: The findings reported here demonstrate the feasibility of this technique and its potential to improve certain aspects of attenuation […]
- Docetaxel in chitosan-based nanocapsules conjugated with an anti-Tn antigen mouse/human chimeric antibody as a promising targeting strategy of lung tumors
The aim of this work was to evaluate the physicochemical and biological properties of docetaxel (DCX) loaded chitosan nanocapsules (CS Nc) […]
- Detection of clinically significant prostate cancer with 18F-DCFPyL PET/multiparametric MR
CONCLUSION: PSMA PET detects more csPCa than mpMR, but at low specificity. The performance PET/MR is better than mpMR for detection of csPCa in […]
- CUTie2: The Attack of the Cyclic Nucleotide Sensor Clones
The detection of small molecules in living cells using genetically encoded FRET sensors has revolutionized our understanding of signaling pathways at […]
- Quantitative 68Ga-DOTATATE PET/CT Parameters for the Prediction of Therapy Response in Patients with Progressive Metastatic Neuroendocrine Tumors Treated with 177Lu-DOTATATE
The aim of this study was to determine whether quantitative PET parameters on baseline ^(68)Ga-DOTATATE PET/CT and interim PET (iPET) performed […]
- Convolutional neural networks for improving image quality with noisy PET data
CONCLUSION: Significant improvements were found for CNN-denoising for very noisy images, and to some degree for all noise levels. The technique […]
- New Orodispersible Mini Tablets of Enalapril Maleate by Direct Compression for Pediatric Patients
CONCLUSION: The three OMDTs with StarLac® showed good quality parameters, according to official requirements. Formulation A exhibited the best […]
- 18F-DCFPyL PET/CT in Patients with Subclinical Recurrence of Prostate Cancer: Effect of Lesion Size, Smoothing Filter, and Partial-Volume Correction on PROMISE Criteria
Our purpose was to determine the effect of a smoothing filter and partial-volume correction (PVC) on measured prostate-specific membrane antigen […]
- Distinctive IGHV gene usage and stereotyped receptors in South American patients with chronic lymphocytic leukemia
No abstract
- Overview of High-Throughput Cloning Methods for the Post-genomic Era
The advent of new DNA sequencing technologies leads to a dramatic increase in the number of available genome sequences and therefore of target genes […]
- Multi-Compartment and Multi-Host Vector Suite for Recombinant Protein Expression and Purification
Recombinant protein expression has become an invaluable tool in basic and applied research. The accumulated knowledge in this field allowed the […]
- Augmented reality and dynamic infrared thermography for perforator mapping in the anterolateral thigh
Dynamic infrared thermography (DIRT) has been used for the preoperative mapping of cutaneous perforators. This technique has shown a positive […]
- Analysis of potential adulteration in herbal medicines and dietary supplements for the weight control by capillary electrophoresis
Four different phytopharmaceutical dosage forms for use in weight control programs were analyzed. Two different ground herbal blends and their […]
- Generation of a vector suite for protein solubility screening
Recombinant protein expression has become an invaluable tool for academic and biotechnological projects. With the use of high-throughput screening […]
- Incidental venous thromboembolism detected by PET-CT in patients with cancer: prevalence and impact on survival rate
CONCLUSION: Incidental VTE was detected in 1.4% of adult patients with cancer undergoing PET-CT imaging. Diagnosis of incidental VTE at PET-CT […]
- Thymoma associated with hypogammaglobulinaemia and pure red cell aplasia
Thymomas are neoplasias that begin in the thymus and develop in the anterior mediastinum. They are commonly associated with a variety of systemic and […]
- Deletions and mutations in the acidic lipid-binding region of the plasma membrane Ca2+ pump: a study on different splicing variants of isoform 2
Acidic phospholipids increase the affinity of the plasma membrane Ca(2+)-ATPase pump for Ca(2+). They interact with the C-terminal region of the pump […]
- Audibility of patient clinical alarms to hospital nursing personnel
The audibility of patient clinical alarms to nursing personnel was tested during the first shift on a medical/surgical in-patient ward at William […]
- Analysis of polymorphic sites in the promoter of the nitric oxide synthase 2 gene
A point mutation (G --> C) in the gene promoter for the human nitric oxide synthase (NOS) 2 at position -954 is associated with protection against […]